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Alison J Cox Selected Research

tranilast

12/20133',4'-Bis-difluoromethoxycinnamoylanthranilate (FT061): an orally-active antifibrotic agent that reduces albuminuria in a rat model of progressive diabetic nephropathy.
1/2011Tranilast attenuates the up-regulation of thioredoxin-interacting protein and oxidative stress in an experimental model of diabetic nephropathy.
12/2009Evaluation and optimization of antifibrotic activity of cinnamoyl anthranilates.
11/2007Tranilast attenuates diastolic dysfunction and structural injury in experimental diabetic cardiomyopathy.
2/2005Tranilast attenuates cardiac matrix deposition in experimental diabetes: role of transforming growth factor-beta.

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Alison J Cox Research Topics

Disease

16Diabetic Nephropathies (Diabetic Nephropathy)
01/2015 - 10/2001
12Fibrosis (Cirrhosis)
02/2015 - 09/2003
8Albuminuria
12/2013 - 08/2007
5Hypertrophy
09/2013 - 08/2004
5Proteinuria
01/2012 - 07/2002
5Hypertension (High Blood Pressure)
08/2011 - 02/2005
3Diabetic Cardiomyopathies
05/2012 - 11/2007
3Heart Failure
05/2012 - 08/2005
2Stroke (Strokes)
09/2013 - 03/2009
2Myocardial Infarction
09/2013 - 08/2005
2Glomerulonephritis
09/2011 - 06/2009
2Nephrotic Syndrome (Syndrome, Nephrotic)
11/2003 - 07/2002
1Chronic Renal Insufficiency
01/2012
1Atopic Dermatitis (Atopic Eczema)
12/2009
1Asthma (Bronchial Asthma)
12/2009
1Kidney Diseases (Kidney Disease)
06/2009
1Diastolic Heart Failure
03/2009
1Systolic Heart Failure
03/2009
1Pathologic Neovascularization
09/2007
1Neoplasms (Cancer)
09/2007
1Diabetic Retinopathy (Retinopathy, Diabetic)
08/2007
1Infarction (Infarctions)
08/2005
1Skin Diseases (Skin Disease)
02/2005
1Heart Diseases (Heart Disease)
02/2005
1Nephrosis
01/2004
1Membranous Glomerulonephritis (Membranous Nephropathy)
01/2004
1Lipoid Nephrosis (Glomerulonephritis, Minimal Change)
11/2003
1Reperfusion Injury
05/2002
1Ischemia
05/2002
1Hypoxia (Hypoxemia)
05/2002

Drug/Important Bio-Agent (IBA)

6CollagenIBA
01/2015 - 10/2001
6Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2012 - 10/2001
5tranilastIBA
12/2013 - 02/2005
5Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
09/2007 - 05/2002
4Pharmaceutical PreparationsIBA
09/2013 - 07/2002
4Protein Kinase CIBA
09/2011 - 08/2005
4Proteins (Proteins, Gene)FDA Link
01/2011 - 05/2002
4ruboxistaurinIBA
06/2009 - 08/2005
4Transforming Growth Factor beta (TGF-beta)IBA
03/2009 - 01/2002
3Glucose (Dextrose)FDA LinkGeneric
01/2015 - 01/2006
3Reactive Oxygen Species (Oxygen Radicals)IBA
01/2015 - 04/2009
3ThioredoxinsIBA
01/2015 - 04/2009
3Messenger RNA (mRNA)IBA
09/2013 - 05/2002
3FT011IBA
09/2013 - 01/2012
3Streptozocin (Streptozotocin)FDA Link
01/2012 - 06/2002
3Protein Isoforms (Isoforms)IBA
09/2011 - 08/2007
3nephrinIBA
06/2009 - 07/2002
3Protein Kinase C betaIBA
06/2009 - 08/2007
2Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
11/2012 - 05/2002
2EnzymesIBA
09/2011 - 06/2009
2Epidermal Growth Factor (EGF)IBA
08/2011 - 01/2002
2Angiotensin IIIBA
08/2011 - 01/2004
2AntioxidantsIBA
01/2011 - 04/2009
2Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
09/2007 - 05/2002
2Membrane Proteins (Integral Membrane Proteins)IBA
01/2004 - 07/2002
2pimagedine (aminoguanidine)IBA
07/2002 - 10/2001
1Hydroxyproline (4 Hydroxyproline)IBA
02/2015
1InflammasomesIBA
01/2015
1Staphylococcal Protein A (Protein A)IBA
01/2015
13-nitrotyrosineIBA
01/2015
1Superoxides (Superoxide)IBA
01/2015
1Catalytic DNA (Deoxyribozyme)IBA
01/2015
13',4'- bis(difluoromethoxycinnamoylanthranilate)IBA
12/2013
1Aligeron (AS 2)IBA
11/2012
1Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA
11/2012
1Losartan (Cozaar)FDA LinkGeneric
11/2012
1Captopril (Capoten)FDA LinkGeneric
11/2012
1C.I. direct red 80IBA
05/2012
1Eosine Yellowish-(YS) (Eosin)IBA
05/2012
1Collagen Type I (Type I Collagen)IBA
05/2012
1Collagen Type III (Type III Collagen)IBA
05/2012
1Platelet-Derived Growth FactorIBA
01/2012
1Transforming Growth Factors (Transforming Growth Factor)IBA
01/2012
1ErbB Receptors (EGF Receptor)IBA
08/2011
1PKI 166IBA
08/2011
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
08/2011
13-methoxy-4-propargyloxycinnamoyl anthranilateIBA
12/2009
1AldosteroneIBA
03/2009
1ReninIBA
03/2009
1Adrenergic Agents (Adrenergic Drugs)IBA
03/2009
1AngiotensinsIBA
03/2009
1Phosphotransferases (Kinase)IBA
09/2007
1anthranilic acid (anthranilate)IBA
02/2005
1Transforming Growth Factor beta1 (TGF beta 1)IBA
02/2005
1Imatinib Mesylate (Gleevec)FDA Link
08/2004
1Puromycin AminonucleosideIBA
01/2004
1CreatinineIBA
01/2004
1SodiumIBA
01/2004
1OsteopontinIBA
06/2002
1Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA
05/2002
1Advanced Glycation End ProductsIBA
10/2001
1CytokinesIBA
10/2001

Therapy/Procedure

9Therapeutics
02/2015 - 07/2002